Synthesis of Dithiols as Reducing Agents for Disulfides in Neutral Aqueous Solution and Comparison of Reduction Potentials
نویسندگان
چکیده
Several dithiols have been prepared that are useful for the reduction of disuffides in aqueous eolution. The reduction potentid of these dithiols have been determined from the measurement of the equilibriun constant of thiol/disulfide interchange with oxidized dithiothreitol using a tH NMR assay. The values of pK" of some of the dithiols were measured to estimate their rate of reduction of disuUides. Bis(2-mercaptoethyl) sulfone (2), NJV'-rlimsthyl-NJV'-bis(mercaptoacetyl)hydrazine (5), and meso-2,5-dimercapto-NJJV',lV'-tetramethyladipamide (6) are especidly interesting as alternatives to dithiothreitol for the reduction of disulfides.
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